Francis Guthrie, 1852
While colouring a map of the counties of England, the young Francis Guthrie noticed that four colours always seemed to suffice. He asked his brother Frederick, who asked their teacher Augustus De Morgan, who asked everyone. The conjecture looked harmless — and stumped mathematicians for 124 years. Several published proofs (Kempe 1879, Tait 1880) turned out to contain subtle gaps that nobody spotted for over a decade.